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. 2014 Dec 10;47(1):66. doi: 10.1186/0717-6287-47-66

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© Fulawka et al.; licensee BioMed Central. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Clonal evolution and CSCs model are not exclusive. The population of CSCs may undergo clonal evolution. Tumour heterogeneity results from existence of both clonal variants and different stages of cell maturation.