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. 2015 Jan 20;12:4. doi: 10.1186/s12950-015-0049-4

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© Kapewangolo et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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The effect of the isolated compound and plant extract on AP-1. The isolated labdane diterpenoid (Lab) and the extract (OL) were tested for activity against the c-Jun component of AP-1 (n = 3) in PHA stimulated PBMCs. Lab significantly (p < 0.05) inhibited AP-1 in PBMCs at 50 μM. NAC (100 μg/mL) was used as positive control and significantly inhibited AP-1 (a). Co-treatment with NAC resulted in stimulation of AP-1 production. At 25 μg/mL, the plant extract significantly stimulated AP-1 in PBMCs (p < 0.05).