Table 5.
Comparing the scoring of the three risk score algorithms as ‘High’ or ‘Low’ risk for Framingham Stroke Risk Score (FSRS), Stroke Riskometer™ and the Qstroke algorithm across all validation cohorts (ARCOS, RUSSIA and ROTTERDAM). Thresholds for ‘High’ risk in each algorithm for males and females was selected for 80% accuracy and >80% specificity (Table 4)
| Algorithm | Comparison | Subset | Number of patients (%) | |||||
|---|---|---|---|---|---|---|---|---|
| RUSSIA | ARCOS | ROTTERDAM | ||||||
| Stroke Riskometer™ vs. FSRS | 5-year risk | 10-year risk | 5-year risk | 10-year risk | 5-year risk | 10-year risk | ||
| Low risk on Stroke Riskometer™ | Low risk on FSRS | Males | 20 (4·16%) | 0 (0·00%) | 2410 (78·63%) | 2522 (82·28%) | ||
| High risk on Stroke Riskometer™ | Low risk on FSRS | 155 (32·22%) | 3 (1·40%) | 275 (8·97%) | 163 (5·32%) | |||
| Low risk on Stroke Riskometer™ | High risk on FSRS | 0 (0·00%) | 1 (0·47%) | 17 (0·55%) | 6 (0·20%) | |||
| High risk on Stroke Riskometer™ | High risk on FSRS | 306 (63·62%) | 210 (98·13%) | 363 (11·84%) | 374 (12·20%) | |||
| Low risk on Stroke Riskometer™ | Low risk on FSRS | Females | 190 (21·18%) | 3 (1·40%) | 4114 (88·51%) | 4188 (90·10%) | ||
| High risk on Stroke Riskometer™ | Low risk on FSRS | 1 (0·11%) | 6 (2·80%) | 194 (4·17%) | 119 (2·56%) | |||
| Low risk on Stroke Riskometer™ | High risk on FSRS | 0 (0·00%) | 0 (0·00%) | 3 (0·00%) | 0 (0·00%) | |||
| High risk on Stroke Riskometer™ | High risk on FSRS | 703 (78·37%) | 185 (86·45%) | 337 (7·25%) | 341 (7·34%) | |||
| Stroke Riskometer™ vs. QStroke | RUSSIA | ARCOS | ROTTERDAM | |||||
|---|---|---|---|---|---|---|---|---|
| Low risk on Stroke Riskometer™ | Low risk on QStroke | Males | 20 (4·16%) | 0 (0·00%) | 2258 (73·67%) | 2346 (76·54%) | ||
| High risk on Stroke Riskometer™ | Low risk on QStroke | 439 (91·27%) | 208 (97·20%) | 376 (12·27%) | 279 (9·10%) | |||
| Low risk on Stroke Riskometer™ | High risk on QStroke | 0 (0·00%) | 1 (0·47%) | 47 (5·51%) | 182 (5·94%) | |||
| High risk on Stroke Riskometer™ | High risk on QStroke | 22 (4·57%) | 5 (2·34%) | 262 (8·55%) | 258 (8·42%) | |||
| Low risk on Stroke Riskometer™ | Low risk on QStroke | Females | 190 (21·18%) | 3 (1·40%) | 3505 (75·41%) | 3557 (76·53%) | ||
| High risk on Stroke Riskometer™ | Low risk on QStroke | 686 (76·48%) | 103 (48·13%) | 168 (3·61%) | 116 (2·50%) | |||
| Low risk on Stroke Riskometer™ | High risk on QStroke | 0 (0·00%) | 0 (0·00%) | 612 (13·17%) | 631 (13·58%) | |||
| High risk on Stroke Riskometer™ | High risk on QStroke | 18 (2·01%) | 88 (41·12%) | 363 (7·81%) | 344 (7·40%) | |||
For FSRS: Male 5-year = 13·0%, Male 10-year = 32·0%, Female 5-year = 19·5%, Female 10-year = 42·0%. For Stroke Riskometer™: Male 5-year = 21·5%, Male 10-year = 43·0%, Female 5-year = 22·0%, Female 10-year = 45·0%. For QStroke: Male 5-year = 8·6%, Male 10-year = 22·0%, Female 5-year = 23·0%, Female 10-year = 48·0%.