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. 2015 Feb 13;10:1291–1306. doi: 10.2147/IJN.S74378

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© 2015 Cabeza et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Evolution of body weight of immunocompetent C57BL/6 mice during and after treatment.

Notes: Weight of mice was measured every 3 d. During and after treatment, treatment with blank NPs did not induce significant weight losses compared with the controls. In contrast, treatment with free DOX and DOX-loaded PBCA NPs always induced a significant mouse body weight loss with respect to the controls (P<0.001). However, the loss induced by treatment with DOX-loaded PBCA NPs was significantly lower (*P<0.001) than the loss caused by free DOX. Data represented as the mean value ± SD (n=10).

Abbreviations: DOX, doxorubicin; PBCA NPs, poly(butylcyanoacrylate) nanoparticles; d, days; SD, standard deviation; DOX-NPs, DOX-loaded PBCA NPs.