Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Feb 13;8:103–113. doi: 10.2147/DMSO.S78771

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2015 Tojo et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

PMC Copyright notice

Pre-embedding immuno-electron microscopy for SGLT2.

Notes: SGLT2 staining was positive in the brush border membrane (marked with *) of the S1 (A) and S2 segments (B) of the proximal convoluted tubules, but not the S3 segment (C) of the proximal straight tubules, in the diabetic rats (upper panel). The SGLT2 expression in the S1 segment of the proximal convoluted tubules in the control rats (D) was enhanced strongly in the DM rats (E), while ARB therapy (F) reversed this increase to the control level (lower panel). The figures for the SGLT2 expression reflect data obtained under starvation conditions, while the results include some findings obtained under fed conditions (data not shown). The arrows indicate apical vesicles. The bar indicates 1 μm. N=3 in each group.

Abbreviations: ARB, angiotensin receptor blocker; SGLT, sodium-glucose co-transporters; DM, diabetes mellitus.