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. 2015 Feb 13;8:103–113. doi: 10.2147/DMSO.S78771

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© 2015 Tojo et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Hepatic gluconeogenesis and glycogen storage.

Notes: The hepatic PEPCK expression evaluated by immunostaining (A) and Western blotting (B) was significantly increased in the diabetic rat compared with that in the control rat. The glycogen concentrations in the liver (C) were significantly increased in the diabetic rats compared with that in the control rats. ARB treatment significantly restored the hepatic glycogen levels. The bar indicates 50 μm. *P<0.01 versus control, ^†P<0.05 versus DM. N=5–7 in each group.

Abbreviations: ARB, angiotensin receptor blocker; PEPCK, phosphoenolpyruvate carboxykinase; DM, diabetes mellitus.