Fig. 3.
Loss of cell surface CD14 after culture with MCSF for 3 days is not due to shedding and these monocytes maintain intracellular levels of CD14. (A) Supernatants from monocytes cultured for 3 days with MCSF were assayed for soluble CD14 (sCD14) by ELISA. The percentage of cells expressing cell surface CD14, as analyzed by FACS, and the levels of sCD14 (ng/ml) in the supernatants are shown. (B) Cell surface CD14 is analyzed by FACS in freshly isolated monocytes (Day 0) and monocytes cultured for 3 days non-adherently with MCSF (Day 3) and intracellular CD14 is analyzed in cells permeabilized before staining with anti-CD14-FITC.