Table 3.
Risk of incident clinical vertebral fracture by category of baseline physical performance in MrOS men
| Test of physical performance | N in group |
N (%) fractured |
Model 1* HR (95% CI) |
Model 2* HR (95% CI) |
|
|---|---|---|---|---|---|
| Repeated chair stands | Unable | 140 | 10 (7.1) | 3.66 (1.68, 7.94) | 3.38 (1.54, 7.40) |
| Quartile 4 (worst) ≥12.6 s | 1419 | 53 (3.7) | 1.58 (0.96, 2.61) | 1.57 (0.95, 2.58) | |
| Quartile 3 ≥10.5 to <12.6 s | 1421 | 26 (1.8) | 0.92 (0.53, 1.59) | 0.93 (0.54, 1.61) | |
| Quartile 2 ≥9.0 to <10.5 s | 1423 | 33 (2.3) | 1.07 (0.64, 1.79) | 1.07 (0.64, 1.79) | |
| Quartile 1 (best) < 8.9 s | 1410 | 27 (1.9) | 1.00 (referent)† | 1.00 (referent)‡ | |
| Leg power | Quartile 1 (worst) <164.7 watts | 1312 | 38 (2.9) | 1.10 (0.58, 2.08) | 1.10 (0.58, 2.08) |
| Quartile 2 ≥164.7 to < 207.4 watts | 1347 | 48 (3.6) | 1.51 (0.86, 2.66) | 1.53 (0.87, 2.69) | |
| Quartile 3 ≥207.4 to <247.8 watts | 1312 | 41 (2.4) | 1.16 (0.65, 2.04) | 1.17 (0.66, 2.07) | |
| Quartile 4 (best) ≥247.8 watts | 1350 | 21 (1.6) | 1.00 (referent) | 1.00 (referent) | |
| Narrow walk | Unable | 439 | 12 (2.7) | 1.08 (0.52, 2.26) | 1.05 (0.50, 2.20) |
| Quartile 4 (worst time) ≥6.2 s | 1350 | 45 (3.3) | 1.19 (0.71, 2.02) | 1.16 (0.69, 1.96) | |
| Quartile 3 ≥5.2 to < 6.2 s | 1340 | 38 (2.8) | 1.19 (0.72, 1.97) | 1.15 (0.69, 1.92) | |
| Quartile 2 ≥4.5 to < 5.2 s | 1342 | 27 (2.0) | 0.93 (0.54, 1.59) | 0.92 (0.54, 1.59) | |
| Quartile 1 (best time) <4.5 s | 1342 | 27 (2.0) | 1.00 (referent) | 1.00 (referent) | |
| Walking speed | Quartile 1 (slowest) <1.06 m/s | 1446 | 47 (3.3) | 1.06 (0.67, 1.70) | 1.02 (0.64, 1.63) |
| Quartile 2 ≥1.06 to < 1.21 m/s | 1452 | 36 (2.5) | 0.85 (0.53, 1.35) | 0.86 (0.54, 1.36) | |
| Quartile 3 ≥1.21 to < 1.36 m/s | 1455 | 25 (1.7) | 0.61 (0.37, 1.02) | 0.60 (0.36, 1.00) | |
| Quartile 4 (fastest) < 1.36 m/s | 1460 | 41 (2.8) | 1.00 (referent) | 1.00 (referent) | |
| Grip strength | Quartile 1 (worst strength) <36.0 kg | 1321 | 43 (3.3) | 1.42 (0.79, 2.56) | 1.43 (0.79, 2.56) |
| Quartile 2 ≥36.0 to <42.0 kg | 1505 | 44 (2.9) | 1.37 (0.80, 2.35) | 1.38 (0.81, 2.37) | |
| Quartile 3 ≥42.0 to <48.0 kg | 1472 | 39 (2.7) | 1.48 (0.87, 2.51) | 1.52 (0.89, 2.58) | |
| Quartile 4 (best strength) ≥48 kg | 1515 | 23 (1.5) | 1.00 (referent) | 1.00 (referent) | |
| Baseline Summary Physical Performance Score (number of tests with poor performance) | 0 (best) | 2157 | 40 (1.9) | 1.00 (referent) | 1.00 (referent) |
| 1–2 | 2294 | 62 (2.7) | 1.24 (0.82, 1.88) | 1.23 (0.81, 1.86) | |
| 3 + (worst) | 1149 | 33 (3.8) | 1.58 (0.95, 2.62) | 1.51 (0.91, 2.51) |
*
Model 1 Adjusted for total lumbar spine bone mineral density, clinical center, smoking status, race, age, height, weight, history of falls, one or more co-morbid conditions and activity level. Model 2 additionally adjusted for prevalent vertebral fracture (assessed by self-report.)
†
P <0.005 across quartiles/groups