Community Education |
Patient delay (probability of seeking care with a 1 year delay) |
41 · 79 days = 0 · 11 probability of a 1 year delay |
[14-17] |
21 days = 0 · 06 probability of a 1 year delay |
Assume 50% reduction in delay days |
DOTS expansion for diagnosis |
Incorrect diagnostic test ordered by heath professional |
0 · 603 |
[18] |
0 · 351 |
[19] |
Diagnostic delay (probability of incurring a 1 year delay) |
29 · 49 days = 0 · 081 probability of a 1 year delay |
[14-17] |
1 · 83 days = 0 · 005 probability of a 1 year delay |
Used pre-intervention data and ratio of delay days "pre" and "post" intervention from [20] to obtain post-intervention estimate of delay days |
Loss to follow up during diagnostic work-up |
0 · 254 |
[21-24] (Assume that loss to follow up is the same for regardless of provider) |
0 · 140 |
Used pre-intervention data and ratio of outcomes "pre" and "post" intervention from [19] to obtain post-intervention estimated of loss to follow up |
DOTS Expansion for Treatment |
Incorrect treatment |
0 · 791 |
[25] |
0 · 129 |
[25] Scenario assumed that incorrect treatment was given regardless of DST availability |
Non specific DOTS Expansion (NTP Strengthening) |
Initial access- inaccessible provider (ie · probability that patient seeks care with alternative provider that is inaccessible to interventions) |
0 · 055 |
[14,26-31] |
0 · 025 |
Intervention assumed to have same impact as in private sector |
Private Sector interventions |
Incorrect diagnostic test ordered by private provider |
0 · 622 |
[18] |
0 · 362 |
[19] |
Diagnostic delay (private sector only) |
0 · 11 |
[14-17] (# days pre-intervention) |
0 · 007 |
Used pre-intervention data and ratio of delay days "pre" and "post" intervention from [20] to obtain post-intervention estimate of delay days and then used ratio of outcomes in public vs private sector from [14] [27,32,33] to extrapolate estimate for public system to private system |
Loss to follow up during diagnosis (private sector only) |
0 · 254 |
[21-24] |
0 · 140 |
Assumed to be same as in public sector (a 45% reduction). Used pre-intervention data and ratio of outcomes "pre" and "post" intervention from [19] to obtain post-intervention estimated of drop out |
Incorrect treatment by private provider |
0 · 771 |
[34] |
0 · 126 |
Used pre-intervention data and ratio of outcomes "pre" and "post" intervention from [25] to obtain post-intervention estimate of incorrect treatment |
HIV/ ART therapy programmes |
TB Death rate in HIV/TB co-infected |
0 · 12 |
[35] |
0 · 10 |
[35] [36,37] (see table S5 in Supplement appendix for more detail) |
TB Relapse rate HIV/TB co-infected |
0 · 16 |
[36] |
0 · 01 |
[35] [36,37] (see table S5 in Supplement appendix for more detail) |
TB Reactivation rate HIV/TB co-infected |
0 · 0340 |
[38-40] |
0 · 02 |
[41] |
MDR-TB related interventions |
DST performed |
0 · 2 |
Assumption |
0 · 5 |
Assumption |
MDR- loss to follow up rate in HIV negative cases |
0 · 22 |
[36] |
0 · 11 |
Assumption- reduce rate to 50% |