Table 5.

Most common serotypes among pneumococcal meningitis isolates in Germany among adults ≥16 years (1992/93-2005/06, n = 605; 2007/08-2009/10, n = 523; 2010/11-2012/13, n = 444)

Adults	1992/93-2005/06		2007/08-2009/10		2010/11-2012/13		P values
Serotypes	(n)	%	(n)	%	(n)	%	pre PCV7 vs post PCV7+13	pre PCV7 vs post PCV7	post PCV7 vs post PCV13
4	43	7.1	12	2.3	3	0.7	<0.0001↓	0.0001↓	0.0644↓
6B	31	5.1	6	1.1	3	0.7	<0.0001↓	0.0002↓	0.5189↓
9V	34	5.6	12	2.3	2	0.5	<0.0001↓	0.0060↓	0.0270↓
14	48	7.9	14	2.7	8	1.9	<0.0001↓	0.0001↓	0.3952↓
18C	17	2.8	13	2.5	9	2.1	0.5094↓	0.8533↓	0.6715↓
19F	36	6.0	25	4.8	14	3.3	0.0892↓	0.4295↓	0.2510↓
23F	54	8.9	18	3.4	5	1.2	<0.0001↓	0.0001↓	0.0198↓
PCV 7	263	43.5	100	19.1	44	9.9	<0.0001↓	<0.0001↓	0.0001↓
1	10	1.7	15	2.9	9	2.1	0.2918↑	0.2232↑	0.5347↓
5	1	0.2	1	0.2	0	0.0	1.0000	1.0000	1.0000
7F	28	4.6	36	6.9	39	9.1	0.0158↑	0.1212↑	0.2799↑
PCV10	302	49.9	152	29.1	92	9.4	<0.0001↓	<0.0001↓	0.0030↓
3	43	7.1	67	12.8	40	9.4	0.0103↑	0.0017↑	0.0645↓
6A	33	5.5	28	5.4	8	1.9	0.1283↓	1.0000	0.0035↓
19A	18	3.0	26	5.0	28	6.6	0.0180↑	0.0912↑	0.4007↑
PCV13	396	65.5	273	52.2	168	17.2	<0.0001↓	<0.0001↓	<0.0001↓
2	2	0.3	0	0.0	0	0.0	0.1480↓	0.5022↓	1.0000
8	19	3.1	14	2.7	14	3.3	0.7636↓	0.7246↓	0.7032↑
9N	14	2.3	15	2.9	13	3.0	0.5245↑	0.5768↑	1.0000
10A	22	3.6	26	5.0	17	4.0	0.5154↑	0.3016↑	0.4360↓
11A	13	2.1	11	2.1	17	4.0	0.4186↓	1.0000	0.1256↑
12F	10	1.7	14	2.7	25	5.9	0.0072↑	0.3013↑	0.0219↑
15B	6	1.0	16	3.1	13	3.0	0.0080↑	0.0161↑	1.0000
17F	6	1.0	3	0.6	3	0.7	0.5530↓	0.5165↓	1.0000
20	2	0.3	3	0.6	4	0.9	0.4958↑	0.6677↑	0.7091↑
22F	21	3.5	33	6.3	25	5.9	0.0321↑	0.0351↑	0.6856↓
33F	10	1.7	10	1.9	8	1.9	0.8463↑	0.8227↑	1.0000
PPV23	488	80.7	511	97.7	375	68	<0.0001↑	0.0146↑	0.0153↓
6C	3	0.5	15	2.9	9	2.1	0.0023↑	0.0016↑	0.5347↓
15C	2	0.3	7	1.3	12	2.8	0.0055↑	0.0900↑	0.1634↑
23A	10	1.7	15	2.9	18	4.2	0.0392↑	0.2232↑	0.3749↑
23B	3	0.5	11	2.1	41	9.6	<0.0001↑	0.0272↑	<0.0001
35B	0	0.0	7	1.3	5	1.2	0.0048↑	0.0045↑	1.0000
others	66	10.9	50	9.6	52	12.2	0.8668↓	0.4921↓	0.2945↑
NVT	84	13.9	105	20.1	137	32.1	<0.0001↑	0.0065↑	0.0001↑

Corrected for multiple comparisons using the Dunn-Šidák test (β = 0.000732493). Arrows indicate increasing or decreasing percentage of serotypes post vaccination.

PCV7: serotypes 4, 6B, 9V, 14, 18C, 19F, 23F; PCV10: PCV7 + serotypes 1, 5, 7F; PCV13: PCV10 + serotypes 3, 6A, 19A; PPV23: PCV13 + serotypes 2, 8, 9N, 10A, 11A, 12F, 15B, 17F, 20, 22F, 33F, but without serotyp 6A; NVT: non-vaccine types, i.e. serotypes not included in any of the above mentioned vaccines.

Significant P values are printed in bold.