Table 6.
Serotype coverage (%) of the 7-, 10-, and 13-valent pneumococcal conjugate vaccines (7v, 10v, 13v), the 23-valent pneumococcal polysaccharide vaccine (23v), and of the serotypes included in the 13- but not in the 7-valent pneumococcal conjugate vaccine (13vnon7v) among children <16 years and adults ≥16 years (1992/93-2005/06, n = 1, 382; 2007/08-2009/10, n = 750; 2010/11-2012/13, n = 638)
| Children <16 years | Adults ≥16 years | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Year | 7v | 10v | 13v | 13v non 7v | 23v | 7v | 10v | 13v | 13v non 7v | 23v |
| 1992-1993 | 52.9 | 52.9 | 82.4 | 29.4 | 64.7 | 43.8 | 56.3 | 64.6 | 20.8 | 81.3 |
| 1993-1994 | 54.5 | 54.5 | 63.6 | 9.1 | 90.9 | 31.0 | 35.7 | 52.4 | 21.4 | 69.0 |
| 1994-1995 | 88.9 | 88.9 | 100.0 | 11.1 | 100.0 | 31.3 | 39.6 | 60.4 | 29.2 | 79.2 |
| 1995-1996 | 75.0 | 75.0 | 75.0 | 0.0 | 87.5 | 41.9 | 51.2 | 67.4 | 25.6 | 93.0 |
| 1996-1997 | 41.2 | 64.7 | 79.4 | 38.2 | 73.5 | 56.0 | 60.0 | 68.0 | 12.0 | 76.0 |
| 1997-1998 | 60.6 | 66.7 | 72.7 | 12.1 | 77.3 | 45.0 | 50.0 | 75.0 | 30.0 | 75.0 |
| 1998-1999 | 64.9 | 73.7 | 84.2 | 19.3 | 93.0 | 48.0 | 52.0 | 72.0 | 24.0 | 80.0 |
| 1999-2000 | 75.0 | 83.9 | 87.5 | 12.5 | 89.3 | 57.1 | 64.3 | 78.6 | 21.4 | 96.4 |
| 2000-2001 | 62.3 | 71.0 | 78.3 | 15.9 | 81.2 | 51.4 | 57.1 | 68.6 | 17.1 | 85.7 |
| 2001-2002 | 57.0 | 68.4 | 78.5 | 21.5 | 89.9 | 42.2 | 42.2 | 53.3 | 11.1 | 73.3 |
| 2002-2003 | 65.3 | 75.0 | 79.2 | 13.9 | 86.1 | 41.1 | 50.0 | 67.9 | 26.8 | 76.8 |
| 2003-2004 | 64.1 | 73.9 | 84.8 | 20.7 | 84.8 | 44.1 | 49.2 | 61.0 | 16.9 | 78.0 |
| 2004-2005 | 60.2 | 68.0 | 81.6 | 21.4 | 82.5 | 39.4 | 50.7 | 70.4 | 31.0 | 78.9 |
| 2005-2006 | 65.4 | 78.8 | 82.7 | 17.3 | 89.4 | 51.7 | 51.7 | 68.3 | 16.7 | 88.3 |
| 1992/93-2005/06 | 62.5 | 72.2 | 81.0 | 18.4 | 85.1 | 43.5 | 49.9 | 65.5 | 22.0 | 80.7 |
| (pre PCV7) | ||||||||||
| 2006-2007 | 47.1 | 63.6 | 80.2 | 33.1 | 85.1 | 35.0 | 46.9 | 64.4 | 29.4 | 80.6 |
| 2007-2008 | 33.3 | 52.0 | 65.3 | 32.0 | 76.0 | 21.3 | 34.4 | 51.9 | 30.6 | 79.2 |
| 2008-2009 | 19.1 | 43.8 | 56.2 | 37.1 | 73.0 | 24.4 | 32.2 | 56.1 | 31.7 | 76.1 |
| 2009-2010 | 15.9 | 44.4 | 60.3 | 44.4 | 73.0 | 10.6 | 19.4 | 48.1 | 37.5 | 67.5 |
| 2007/08-2009/10 | 22.9 | 46.7 | 60.4 | 37.4 | 74.0 | 19.1 | 29.1 | 52.2 | 33.1 | 74.6 |
| (post PCV7) | ||||||||||
| 2010-2011 | 11.4 | 21.5 | 40.5 | 29.1 | 55.7 | 13.4 | 25.6 | 49.4 | 36.0 | 74.4 |
| 2011-2012 | 5.6 | 24.1 | 33.3 | 27.8 | 64.8 | 9.2 | 22.0 | 36.9 | 27.7 | 67.4 |
| 2012-2013 | 0.0 | 1.6 | 11.5 | 11.5 | 52.5 | 6.5 | 13.7 | 25.2 | 18.7 | 59.0 |
| 2010/11-2012/13 | 6.2 | 16.0 | 29.4 | 23.2 | 57.2 | 9.9 | 20.7 | 37.8 | 27.9 | 67.3 |
| (post PCV13) | ||||||||||
| pre7 vs. post7+post13 | <0.0001 | <0.0001 | <0.0001 | 0.0137 | 0.0004 | <0.0001 | <0.0001 | 0.0001 | 0.0140 | 0.0130 |
| pre7 vs. post7 | <0.0001 | 0.0010 | 0.0010 | 0.0024 | 0.0539 | 0.0001 | 0.0005 | 0.0065 | 0.0096 | 0.1900 |
| post7 vs. post13 | 0.0529 | 0.0148 | 0.0243 | 0.0887 | 0.0129 | 0.1219 | 0.2328 | 0.1130 | 0.3448 | 0.2637 |
Corrected for multiple comparisons using the Dunn-Šidák test (β = 0. 001708316).