Table 7.
Antibiotic susceptibilities of pneumococcal meningitis isolates among children <16 years and adults ≥16 years in Germany from 1992/93 to 2012/13
| Children <16 years | Adults ≥16 years | CLSI breakpoints (mg/L) | ||||||
|---|---|---|---|---|---|---|---|---|
| I% | R% | n | I% | R% | n | I | R | |
| Penicillin G, meningitis | 0.0 | 7.2 | 1,317 | 0.0 | 7.2 | 1,731 | - | ≥0.12 |
| Cefotaxime, meningitis | 0.8 | 0.5 | 1,317 | 0.9 | 0.2 | 1,729 | 1 | ≥2 |
| Macrolides* | 0.1 | 19.8 | 1,317 | 0.1 | 10.8 | 1,730 | 0.5 | ≥1 |
| Clindamycin | 0.2 | 5.9 | 1,316 | 0.5 | 5.7 | 1,730 | 0.5 | ≥1 |
| Tetracycline | 0.4 | 9.2 | 1,316 | 0.9 | 8.9 | 1,731 | 2 | ≥4 |
| Levofloxacin | 0.2 | 0.3 | 874 | 0.2 | 0.1 | 1,326 | 4 | ≥8 |
| SXT | 6.1 | 5.7 | 870 | 7.1 | 5.5 | 1,318 | 1/19-2/38 | ≥4/76 |
I, intermediately-resistant; R, resistant; n, number of isolates. SXT, trimethoprim-sulfamethoxazole. MIC breakpoints according to CLSI M100-S24, 2014 [20].
*Macrolides: erythromycin or clarithromycin.