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. Author manuscript; available in PMC: 2015 Feb 20.
Published in final edited form as: J Thromb Thrombolysis. 2013 Apr;35(3):352–358. doi: 10.1007/s11239-013-0895-y

Table 1.

Factors influencing development of VTE in SCD patients

Traditional risk factors SCD-related factors
Central venous catheters (CVCs) for
 poor venous access, transfusion
 therapy		 Increased prevalence of
 thrombophilic defects
  • Totally implantable CVCs (port)  • Anti-phospholipid
 antibodies
  • Partially implantable CVCs
 (tunneled and nontunneled lines)		  • Protein C/S deficiency
Genotype (SS/S•0 vs. SC/
 S•+)
Frequent hospitalization for pain and
 complications		 Splenectomy
Surgery  • Surgical
  • Orthopedic surgery (hip, shoulder
 avascular necrosis)		  • Functional asplenia?
  • Cholecystectomy
Pregnancy

VTE venous thromboembolism, SCD sickle cell disease