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. Author manuscript; available in PMC: 2015 May 27.
Published in final edited form as: N Engl J Med. 2014 Nov 12;371(22):2072–2082. doi: 10.1056/NEJMoa1405386

Figure 2. Association between the Presence of Inactivating Mutations in NPC1L1 and LDL Cholesterol Levels, According to Genetic Ancestry.

Figure 2

In each group of participants, we tested the association between the presence of inactivating mutations in NPC1L1 and plasma levels of low-density lipoprotein (LDL) cholesterol, after adjustment for age, sex, and study. The squares indicate the estimated adjusted difference in the LDL cholesterol level for carriers, as compared with noncarriers, in each ancestry group. The sizes of the squares are inversely proportional to the variance of the estimates. The diamonds indicate the combined results, based on a fixed-effects meta-analysis performed first within and then across ancestry groups. Participants from population-based studies — the Atherosclerosis Risk in Communities (ARIC) study, the Jackson Heart Study (JHS), and the Women’s Genome Health Study (WGHS) — and controls without coronary heart disease (CHD) from case–control studies were included in this analysis. To convert the values for cholesterol to millimoles per liter, multiply by 0.02586.