Table 2.

Association between the Presence of Inactivating Mutations in NPC1L1 and Plasma Lipid Levels.^*

Variable	Mean Difference between Carriers and Noncarriers*	P Value
Cholesterol (mg/dl)
Total	−13	0.03
Low-density lipoprotein	−12	0.04
High-density lipoprotein	2	0.29
Triglycerides (% change)	−12	0.11†

^*The mean difference is the summary effect estimate for carriers of inactivating mutations in NPC1L1, as compared with noncarriers, after adjustment for age, sex, and study. Participants from population-based studies (ARIC, JHS, and WGHS) and controls without coronary heart disease from case–control studies were included in this analysis. To convert the values for cholesterol to millimoles per liter, multiply by 0.02586.

^†This P value was calculated with the use of natural log transformation of the values.