Table 3A.
Age- and European ancestry-adjusted Odds Ratios (OR) and 95% Confidence Intervals (CI) for associations between VDR variants and Ovarian Cancer among Caucasians
| Cases | Controls | Age- and Ancestry-adjusted | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| All* | Invasive** | All | All* | Invasive** | ||||||
| N | (%) | N | (%) | N | (%) | OR | (95%CI) | OR | (95% CI) | |
| rs7975232 Apa1 | ||||||||||
| AA | 138 | (27.2) | 105 | (26.8) | 148 | (27.8) | ||||
| AC | 262 | (51.7) | 204 | (52.0) | 261 | (49.1) | ||||
| CC | 107 | (21.1) | 83 | (21.2) | 123 | (23.1) | ||||
| AC/CC | 369 | (72.8) | 287 | (73.2) | 384 | (72.2) | ||||
| Log-additive | 0.97 | (0.82, 1.15) | 0.97 | (0.80, 1.17) | ||||||
| Total | 507 | 392 | 532 | |||||||
| rs2228570 Fok1 | ||||||||||
| GG | 197 | (38.5) | 158 | (39.9) | 203 | (38.2) | ||||
| AG | 250 | (48.8) | 185 | (46.7) | 256 | (48.2) | ||||
| AA | 65 | (12.7) | 53 | (13.4) | 72 | (13.6) | ||||
| AG/AA | 315 | (61.5) | 238 | (60.1) | 328 | (61.8) | ||||
| Log-additive | 0.98 | (0.82, 1.17) | 0.97 | (0.80, 1.17) | ||||||
| Total | 512 | 396 | 531 | |||||||
| rs731236 Taq1 | ||||||||||
| TT | 168 | (32.9) | 131 | (33.2) | 198 | (37.4) | ||||
| TC | 266 | (52.1) | 205 | (51.9) | 243 | (45.8) | ||||
| CC | 77 | (15.1) | 59 | (14.9) | 89 | (16.8) | ||||
| TC/CC | 343 | (67.1) | 264 | (66.8) | 332 | (62.6) | ||||
| Log-additive | 1.06 | (0.89, 1.27) | 1.06 | (0.88, 1.28) | ||||||
| Total | 511 | 395 | 530 | |||||||
| rs1544410 Bsm1 | ||||||||||
| CC | 165 | (33.1) | 129 | (33.5) | 192 | (36.7) | ||||
| CT | 257 | (51.6) | 197 | (51.2) | 244 | (46.7) | ||||
| TT | 76 | (15.3) | 59 | (15.3) | 87 | (16.6) | ||||
| CT/TT | 333 | (66.9) | 256 | (66.5) | 331 | (63.3) | ||||
| Log-additive | 1.05 | (0.88, 1.25) | 1.05 | (0.87, 1.27) | ||||||
| Total | 498 | 385 | 523 | |||||||
| rs2239179 | ||||||||||
| TT | 142 | (28.1) | 111 | (28.4) | 168 | (31.8) | ||||
| TC | 275 | (54.3) | 211 | (54.0) | 267 | (50.5) | ||||
| CC | 89 | (17.6) | 69 | (17.6) | 94 | (17.8) | ||||
| TC/CC | 364 | (71.9) | 280 | (71.6) | 361 | (68.2) | ||||
| Log-additive | 1.08 | (0.90, 1.29) | 1.08 | (0.89, 1.31) | ||||||
| Total | 506 | 391 | 529 | |||||||
| rs3782905 | ||||||||||
| GG | 214 | (42.2) | 171 | (43.6) | 243 | (46.2) | ||||
| GC | 237 | (46.7) | 177 | (45.2) | 231 | (43.9) | ||||
| CC | 56 | (11.0) | 44 | (11.2) | 52 | (9.9) | ||||
| GC/CC | 293 | (57.8) | 221 | (56.4) | 283 | (53.8) | ||||
| Log-additive | 1.13 | (0.94, 1.36) | 1.11 | (0.91, 1.35) | ||||||
| Total | 507 | 392 | 526 | |||||||
| rs7968585 | ||||||||||
| AA | 132 | (26.0) | 101 | (25.7) | 144 | (27.2) | ||||
| AG | 262 | (51.6) | 203 | (51.7) | 252 | (47.5) | ||||
| GG | 114 | (22.4) | 89 | (22.6) | 134 | (25.3) | ||||
| AG/GG | 376 | (74.0) | 292 | (74.3) | 386 | (72.8) | ||||
| Log-additive | 0.97 | (0.81, 1.15) | 0.97 | (0.81, 1.17) | ||||||
| Total | 508 | 393 | 530 | |||||||
*
including all peritoneal cases
**
including serous invasive peritoneal cases