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. Author manuscript; available in PMC: 2015 Feb 20.
Published in final edited form as: J Neurochem. 2008 Feb 13;105(5):1948–1959. doi: 10.1111/j.1471-4159.2008.05295.x

Scheme 1.

Scheme 1

Putative mechanisms of Mn-induced neurodegeneration involving p53 related genes. Arrows next to gene name indicate if the gene is increased or decreased in Mn-exposed frontal cortex. Number next to gene designation represents the citation documenting the effect described: 1 (HaMai and Bondy 2004); 2 (Hirata 2002); 3 (Latchoumycandane et at. 2005); 4 (Culmsee and Mattson 2005); 5 (Miller et a1. 2000); 6 (Tang et al. 2007); 7 (Lu et al. 1997); 8 (Ko et al. 1997); 9 (Wang et al. 1995); 10 (Laine et al. 2006); 11 (Morimoto et al. 2002); 12 (Wang et al. 2001); 13 (Shin et al. 1995); 14 (Cervoni et al. 2006); 15 (Matsui et al. 2004); 16 (Romier et al. 2003); 17 (Jin et al. 2006); 18 (Galvan et al. 2002); 19 (Dumanchin-Njock et al. 2001).