TABLE 1.

MICs for T-2307 (0.008 to 4 μg/ml) and caspofungin (0.03 to 8 μg/ml) against 37 C. albicans isolates, including caspofungin-susceptible (n = 17), caspofungin-intermediate (n = 2), and caspofungin-resistant (n = 18) strains

Isolate type (no. of isolates)	MIC data (μg/ml) for indicated antifungal agent
	T-2307 (50% inhibition)	T-2307 (100% inhibition)	Caspofungin
All Candida albicans (37)
MIC range	≤0.008	0.008 to >4	0.06 to >8
MIC50	≤0.008	>4	0.5
MIC90	≤0.008	>4	>8
GM MICa	0.008	>4	0.4548
Echinocandin susceptible (17)
MIC range	≤0.008	0.008 to >4	0.06 to 0.125
MIC50	≤0.008	>4	0.125
MIC90	≤0.008	>4	0.125
GM MIC	0.008	3.836	0.1197
Echinocandin resistant (18)
MIC range	≤0.008	0.008 to >4	1 to >8
MIC50	≤0.008	>4	1
MIC90	≤0.008	>4	8
GM MIC	0.008	3.996	1.587

^aGM MIC, geometric mean MIC.