FIG 5.

Phenotypic susceptibility of mutants with single and double NNRTI resistance-associated mutations. The in vitro phenotypic responses of mutants with site-directed single and double NNRTI resistance-associated mutations, ranked according to the prevalence of the mutation among the 1,433 sequences with NNRTI resistance-associated mutations used in this analysis, are summarized. Some mutations (*) were not observed among the sequences but were included, as they are implicated in ETR and RPV resistance. Light gray shading, FCs of >3.6 (ETR), >2.6 (RPV), >3.8 (EFV), and >2.8 (NVP); dark gray shading, FC of >10.