TABLE 2.
Pairs of positively correlated NNRTI resistance-associated amino acid substitutions
| Combination | P value for association | Prevalence (%) |
|---|---|---|
| Subtype C data seta | ||
| K101E-G190A | <0.0001 | 5.6 |
| K103N-P225H | <0.0001 | 7.7 |
| V106M-V179D | <0.0001 | 4.4 |
| V106M-F227L | <0.0001 | 4.0 |
| Y181C-H221Y | <0.0001 | 3.5 |
| Subtype B data setb | ||
| Y181C-G190A | <0.0001 | 6.5 |
| K101E-G190A | <0.0001 | 3.4 |
| K101E-Y181C | <0.0001 | 2.7 |
| K101E-G190S | <0.0001 | 1.0 |
| H101H-G190A | <0.0001 | 0.9 |
| A98G-Y181C | <0.0001 | 2.4 |
| K101H-Y181C | <0.0001 | 0.7 |
| A98G-G190A | <0.0001 | 1.6 |
| Y181C-G190S | <0.0001 | 0.9 |
| V179F-Y181C | <0.0001 | 0.2 |
a
From 1,433 subtype C sequences with NNRTI resistance-associated mutations from the SATuRN and Stanford databases.
b
From 13,039 published subtype B sequences (25).