TABLE 1.
Activities against schistosomula determined by lactate assay and microscopy and previously reported activitiesa
| Compound | Activity (μM) by lactate assay |
MLC (μM) by microscopy | Previously reported activity |
||||
|---|---|---|---|---|---|---|---|
| IC50 | IC50 range | IC99 | IC99 range | MLC (μM) | Authors, yr (reference) | ||
| MQ | 9.02 | (4.76–13.2) | 13.0 | (6.09–19.7) | 5.55 | 12.1 | Manneck et al., 2010 (32) |
| AU | 0.64 | (0.32–0.77) | 2.43 | (1.80–4.01) | 1.10 | 1b | Abdullah et al., 2009 (27) |
| GA | 0.93 | (0.61–1.49) | 12.2 | (0.91–75.3) | 0.62 | 1 | Abdullah et al., 2009 (27) |
| SAL | 32.6 | (5.59–140.1) | 6,692 | (17.3–54,487) | 4.29 | 1 | Abdullah et al., 2009 (27) |
| PZQ | NA | NA | NA | NA | NA | >320 | Manneck et al., 2011 (11) |
| NI | NA | NA | NA | NA | 0.21 | 1 | Abdullah et al., 2009 (27) |
a
MLC, minimum lethal concentration; NA, not applicable.
b
The IC50 was 0.82 μM by FDA-PI staining (13).