TABLE 5.
Isolates with MRR1 polymorphisms
| Nucleotide (amino acid) polymorphism | Isolate | Hospital | Fluconazole MICa (μg/ml) | Note |
|---|---|---|---|---|
| G−53A | CAS08-0060 | ATL12 | 16 (R) | |
| CAS08-0419 | ATL05 | 16 (R) | ||
| CAS10-2578 | ATL14 | 4 (SDD) | ||
| C1856T (A619V) | CAS09-1299 | ATL01 | 8 (R) | Heterozygous |
| CAS09-1761 | ATL01 | 4 (SDD) | Heterozygous | |
| G1214A (R405K) | CAS10-1852 | BAL05 | 8 (R) | |
| CAS09-1025 | ATL05 | 4 (SDD) | ||
| CAS13-4604 | ATL14 | 0.5 (S) | ||
| G531T (K177N) | CAS10-1830 | BAL06 | 8 (R) | |
| CAS12-4406 | KNX01 | 8 (R) | ||
| CAS08-0029 | ATL01 | 0.5 (S) | ||
| CAS10-2116 | BAL06 | 0.5 (S) | ||
| CAS12-4166 | BAL09 | 2 (S) | ||
| C3157T (Q1053X) | CAS10-1830 | BAL06 | 8 (R) | Heterozygous |
| CAS08-0029 | ATL01 | 0.5 (S) | Heterozygous | |
| CAS10-2116 | BAL06 | 0.5 (S) | Heterozygous | |
| A1844G (D615G) | CAS11-3108 | ATL03 | 8 (R) | Heterozygous |
| CAS09-0941 | BAL01 | 4 (SDD) | Heterozygous | |
| CAS10-1841 | BAL09 | 4 (SDD) | Heterozygous | |
| CAS09-1196 | ATL03 | 0.25 (S) | ||
| CAS10-2702 | BAL02 | 0.5 (S) | ||
| G2575A (A859T) | CAS08-0339 | BAL02 | 8 (R) | Heterozygous |
| C744T (no change) | CAS09-1025 | ATL05 | 4 (SDD) | Heterozygous |
| C1139A (P380H) | CAS12-4003 | POR01 | 1 (S) | Heterozygous |
| −102_−101insT | CAS12-4480 | BAL04 | 8 (R) | |
| G2337T (L779F) | CAS12-4342 | ATL03 | 32 (R) | |
| G1436A (R478K) | CAS13-4861 | ATL05 | 4 (SDD) | Heterozygous |
a
R, resistant; SDD, susceptible dose dependent; S, susceptible.