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NB95029 demonstrates increased toxin B levels at subinhibitory concentrations of vancomycin. Strain NB95029 was grown for 24 h in the presence of the indicated antibiotics. Remaining viable cells (log10 CFU/ml, lines) and toxin B production (A450–620, bars) were measured. FDX, fidaxomicin; VAN, vancomycin; MET, metronidazole. Data are mean and SEM of duplicate antibiotic treatments; toxin B values for samples treated with metronidazole represent a single experiment.
