FIG 1.
Effects of anti-ftsZ PLNA787 on the growth of MSSA or MRSA on MH agar. (A) CFU of ATCC 29213 in the presence of 0.78, 1.56, 3.13, or 6.25 μM PLNA787. (B) CFU of Mu50 in the presence of 0.39, 0.78, 1.56, or 3.13 μM PLNA787. (C) CFU of MRSA01 in the presence of 1.56, 3.13, 6.25, or 12.5 μM PLNA787. (D) CFU of MRSA02 in the presence of 0.78, 1.56, 3.13, or 6.25 μM PLNA787. The indicated concentrations of PLNA787, or an equal volume of phosphate-buffered saline as a control (Cont), were added to cell cultures containing 1.5 × 108 CFU/ml. Aliquots of each culture were collected at 6 h, diluted, and inoculated on solid agar for 24 h. CFU values were calculated from the numbers of colonies growing on the plates. Data represent the mean ± SD (n = 10). *, P < 0.05; **, P < 0.01, versus control.