TABLE 1.
MICs of anti-ftsZ PLNA and antibiotics in MSSA and MRSA isolates in MH broth cultures
| PLNA or antibiotic | MIC of strain:a |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| ATCC 29213 | Mu50 | WHO-2 | MRSA01 | MRSA02 | MRSA03 | MRSA04 | MRSA05 | MRSA06 | MRSA07 | |
| PLNA787 (μM) | 3.13 | 1.56 | 12.5 | 6.25 | 3.13 | 6.25 | 12.5 | 12.5 | 6.25 | 3.13 |
| Free LNA787 (μM) | >50 | >50 | >50 | >50 | >50 | >50 | >50 | >50 | >50 | >50 |
| Free (KFF)3K (μM) | >50 | >50 | >50 | >50 | >50 | >50 | >50 | >50 | >50 | >50 |
| Scrambled PLNA (μM) | >50 | >50 | >50 | >50 | >50 | >50 | >50 | >50 | >50 | >50 |
| OXA (μg/ml) | 0.5 (S) | 256 (R) | 1,024 (R) | 1,024 (R) | 256 (R) | 512 (R) | 1,024 (R) | 1,024 (R) | 256 (R) | 128 (R) |
| AMP (μg/ml) | 1 (S) | 256 (R) | 1,024 (R) | 1,024 (R) | 256 (R) | 512 (R) | 1,024 (R) | 1,024 (R) | 256 (R) | 128 (R) |
| CAZ (μg/ml) | 8 (S) | 512 (R) | 256 (R) | 128 (R) | 256 (R) | 16 (I) | 8 (S) | 512 (R) | 128 (R) | 64 (R) |
| LVX (μg/ml) | 0.5 (S) | 128 (R) | 128 (R) | 256 (R) | 32 (R) | 2 (I) | 16 (R) | 256 (R) | 128 (R) | 64 (R) |
a
Data are derived from 3 independent experiments. OXA, oxacillin; AMP, ampicillin; CAZ, ceftazidime; LVX, levofloxacin; MH, Mueller-Hinton; MRSA, methicillin-resistant Staphylococcus aureus; MSSA, methicillin-sensitive Staphylococcus aureus; PLNA, peptide-locked nucleic acid; R, resistant; I, intermediate; S, susceptible.