TABLE 1.
AUC0–24 values and population pharmacokinetic model parameters from the developed model and from the n − 1 models from the cross-validation
| Parametera | Model | Validation | P value |
|---|---|---|---|
| AUC0–24 (mg · h/liter) | 64.0 (55.3–84.2) | 64.0 (55.3–84.2) | 0.254 |
| CL (liter/h/56 kg FFM) | 1.26 (1.10–1.71) | 1.26 (1.11–1.71) | 0.062 |
| V1 (liter/kg LBMc) | 0.401 (0.338–0.529) | 0.401 (0.335–0.530) | 0.131 |
| Q (liter/h/56 kg FFM) | 7.79 (7.32–8.45) | 7.81 (7.48–8.39) | 0.550 |
| V2 (liter/kg LBMc) | 0.514 (0.439–0.657) | 0.520 (0.442–0.659) | 0.334 |
a
AUC0–24, area under the concentration-time curve over a 24-h dosing interval; CL, clearance; FFM, fat-free mass; LBMc, lean body mass corrected; V1, central volume of distribution; Q, intercompartmental clearance; V2, peripheral volume of distribution.