TABLE 2.

Antiviral activity of ABT-450 in transient HCV replicon assays using chimeric replicons containing NS3 protease genes from HCV genotype 1-infected patients

Genotype	Samplea	EC50, nM
1a	1a-H77	0.96
	1	0.43
	2	0.69
	3	0.65
	4	1.87
	5	0.60
	6	0.65
	7	0.89
	8	0.68
	9	1.30
	10	0.62
	11	1.03
	Mean	0.86
1b	1b-Con1	0.033
	1	0.062
	2	0.046
	3	0.056
	4	0.058
	5	0.087
	6	0.033
	7	0.043
	8	0.074
	9	0.067
	Mean	0.058

^aGenBank accession numbers for 1a-H77 and 1b-Con1 are AF011751 and AJ238799, respectively. Infected patient samples were obtained from ProMedDx (Norton, MA).