TABLE 2.
pfcrt K76T frequencies, pfmdr1 N86Y frequencies, and pfmdr1 gene copy numbers between 2003 and 2012 among children diagnosed with P. falciparum malaria at the Bandim Health Centre
| Yr | Frequency (% [no. with a specific allele/total no. of successfully amplified samples]) for: |
No. of samples with pfmdr1 copy no. of: |
|||||||
|---|---|---|---|---|---|---|---|---|---|
|
pfcrt |
pfmdr1 |
||||||||
| K76 | 76T | N86 | 86Y | F184 | 184Y | 1 | 1.5 | 2 | |
| 2003 | 79 (253/318) | 24 (75/318) | 72 (227/317) | 47 (149/317) | 79 (251/317) | 37 (118/317) | 311 | ||
| 2004 | 79 (119/151) | 25 (37/151) | 70 (108/155) | 43 (66/155) | 152 | ||||
| 2005 | 80 (136/169) | 23 (39/169) | 79 (134/170) | 36 (61/170) | 173 | ||||
| 2006 | 84 (74/88) | 23 (20/88) | 80 (70/88) | 42 (37/88) | 88 | ||||
| 2007a | 80 (32/40) | 25 (10/40) | 63 (25/40) | 48 (19/40) | 39 | ||||
| 2008 | 71 (95/134) | 31 (42/134) | 71 (96/135) | 36 (49/135) | 138 | 1 | |||
| 2010 | 65 (193/296) | 48 (141/296) | 78 (232/297) | 30 (89/297) | 76 (218/288) | 42 (121/288) | 271 | 1 | 1 |
| 2011 | 65 (224/345) | 57 (195/345) | 77 (249/322) | 29 (93/322) | 74 (245/332) | 41 (136/332) | 337 | ||
| 2012 | 71 (86/121) | 34 (41/121) | 83 (105/126) | 34 (43/126) | 79 (73/92) | 46 (42/92) | 126 | ||
a
pfcrt K76T and pfmdr1 N86Y frequencies did not change significantly before 2007. pfcrt K76 decreased (P < 0.001) and pfcrt 76T increased (P < 0.001) after 2007. pfmdr1 N86 increased and pfmdr1 86Y decreased significantly (both P < 0.001) between 2007 and 2012. pfmdr1 Y184F did not change significantly.