TABLE 3.
Pfcrt K76T and pfmdr1 N86Y haplotype frequencies between 2003 and 2012 among children diagnosed with P. falciparum malaria at the Bandim Health Centre
| Yr |
pfcrt K76T + pfmdr1 N86Y haplotype |
pfmdr1 N86Y + pfmdr1 F184Y haplotype |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Total no. of samples | Frequency (% [no. of samples with haplotype]) for: |
Total no. of samples | Frequency (% [no. of samples with haplotype]) for: |
|||||||
| KNa | KYa | TNb | TY | NFc | NY | YFd | YY | |||
| 2003 | 254 | 56 (142) | 23 (59) | 9 (24) | 11 (29) | 223 | 39 (87) | 22 (49) | 37 (82) | 2 (5) |
| 2004 | 129 | 56 (72) | 21 (27) | 9 (11) | 15 (19) | |||||
| 2005 | 139 | 65 (91) | 14 (20) | 10 (14) | 10 (14) | |||||
| 2006 | 65 | 63 (41) | 15 (10) | 11 (7) | 11 (7) | |||||
| 2007 | 36 | 47 (17) | 31 (11) | 11 (4) | 11 (4) | |||||
| 2008 | 121 | 46 (56) | 23 (28) | 22 (27) | 8 (10) | |||||
| 2010 | 263 | 50 (132) | 10 (26) | 26 (68) | 14 (37) | 221 | 52 (116) | 25 (55) | 19 (41) | 4 (9) |
| 2011 | 263 | 46 (122) | 12 (31) | 29 (75) | 13 (35) | 246 | 46 (114) | 27 (66) | 22 (54) | 5 (12) |
| 2012 | 89 | 54 (48) | 10 (9) | 27 (24) | 9 (8) | 50 | 66 (33) | 24 (12) | 10 (5) | 0 (0) |
a
KN (P = 0.002) and KY (P < 0.001) frequencies decreased over time.
b
TN frequency increased between 2007 and 2012 (P = 0.001).
c
NF frequency increased (P = 0.004).
d
YF frequency decreased over time (P < 0.001).