FIG 1.

Amino acid sequence variability of Vga(A)* variants mined from the NCBI protein database. Only variable positions are shown. Amino acid residues that differ from those in Vga(A) are indicated by a gray background. Specific residues important for antibiotic specificity of Vga(A) and Vga(A)_LC are indicated by light green and light bronze background, respectively (4). In the Resistance phenotype^a column, the superscript letter a indicates that the resistance phenotype as published in the relevant reference is shown as follows: SgA, streptogramins A; L, lincosamides; P, pleuromutilins; CLI, clindamycin. The superscript letter b indicates that pleuromutilins were not tested, and the superscript letter c indicates that only CLI was tested.