TABLE 4.
Doses and fAUC of MK7655 required for a static effect during treatment with IMP/C with various dosing regimens
| Strain | Imipenem |
MK7655 |
|||||
|---|---|---|---|---|---|---|---|
| Dose (mg/kg) | TDDa (mg/kg) | MIC (mg/liter) | fT>MIC (%) | Static TDD (mg/kg) | Static fAUCb (mg · h/liter) | MIC/4c (mg/liter) | |
| 6339 | 1 | 12 | 16 | 0 | 0.25 | ||
| 2 | 24 | 16 | 0 | 0.25 | |||
| 4 | 48 | 16 | 0 | 0.25 | |||
| 8 | 96 | 16 | 0 | 11.8 | 6.3 | 0.25 | |
| 6755 | 8 | 96 | 4 | 22.4 | 75.9 | 40.3 | 0.125 |
| 15.9 | 190.8 | 4 | 34.1 | 39.8 | 21.2 | 0.125 | |
| 24266 | 1 | 12 | 8 | 0 | 0.5 | ||
| 2 | 24 | 8 | 0 | 61.7 | 32.8 | 0.5 | |
| 4 | 48 | 8 | 0 | 79.4 | 42.2 | 0.5 | |
| 8 | 96 | 8 | 10.5 | 23.4 | 12.5 | 0.5 | |
| 24354 | 8 | 96 | 32 | 0 | 85.1 | 45.2 | 2 |
| 24227 | 8 | 96 | 4 | 22.4 | 12 | 6.4 | 0.25 |
| 24228 | 15.9 | 190.8 | 8 | 22.3 | 51.3 | 27.2 | 0.5 |
| Mean | 48.9 | 26.0 | |||||
| SD | 27.1 | 14.4 | |||||
a
TDD, total daily dose of imipenem.
b
The static fAUC indicates the exposure of MK7655 to result in a static effect with the imipenem regimes.
c
MIC/4, imipenem MIC in the presence of 4 mg/liter MK7655.