TABLE 3.
Sensitivity of recently laboratory-adapted P. falciparum isolates to the 1,2,4-oxadiazole series compounds
| Compound | IC50 (nM)a |
Ratio of IC50 for HL1210/IC50 for HL1212 | |
|---|---|---|---|
| HL1210 | HL1212 | ||
| Chloroquine | 150.0 ± 7.0 | 12.0 ± 3.0 | 12.5 |
| Artesunate | 4.2 ± 1.1 | 7.1 ± 1.2 | 0.6 |
| Pyrimethamine | >10,000.0 | >10,000.0 | NAb |
| Cycloguanil | 879.0 ± 218.0 | 1,877.0 ± 156.0 | 0.5 |
| 1 | 2,270.0 ± 548.0 | 33.0 ± 10.0 | 68.8 |
| 2 | 2,694 ± 502.0 | 44.0 ± 11.0 | 61.3 |
| 3 | >10,000.0 | 98.0 ± 26.0 | >100 |
a
Data are means and standard errors of the means from at least five independent experiments.
b
NA, not applicable.