TABLE 2.
Antiviral activity of nitazoxanide against different strains of influenza A virusa
| Virus | IC50 (μM) | IC90 (μM) | LD50 (μM) | SI |
|---|---|---|---|---|
| PR8 | 3.2 ± 0.0 | 26.0 ± 2.5 | >163.0 | >50.9 |
| WSN | 1.6 ± 0.2 | 16.3 ± 2.3 | >163.0 | >101.9 |
| CA09 | 3.2 ± 0.0 | 20.8 ± 0.0 | >163.0 | >50.9 |
| OST-R | 1.9 ± 0.0 | 21.1 ± 0.0 | >163.0 | >85.8 |
| AMD-R | 1.0 ± 0.0 | 13.0 ± 0.0 | >163.0 | >163.0 |
| A/Ck | 3.2 ± 0.5 | 26.0 ± 2.3 | >163.0 | >50.9 |
| A/Gs | 3.2 ± 0.2 | 26.8 ± 2.6 | >163.0 | >50.9 |
| A/Tk | 1.6 ± 0.2 | 20.5 ± 4.7 | >163.0 | >101.9 |
a
Virus yield was determined at 24 h p.i. by HA titration. Data are the means ± SD of results from quadruplicate samples. PR8, A/Puerto Rico/8/1934 (H1N1); WSN, A/WSN/1933 (H1N1); CA09, A/California/7/2009 (H1N1pdm09); OST-R, oseltamivir-resistant A/Parma/24/2009 (H1N1); AMD-R, amantadine-resistant A/Parma/06/2007 (H3N2); A/Ck, A/chicken/Italy/9097/1997 (H5N9); A/Gs, A/goose/Italy/296246/2003 (H1N1); A/Tk, A/turkey/Italy/RA5563/1999 (H7N1).