FIG 5.

Twelve s.c. doses of micellar ecumicin (ECM) inhibit M. tuberculosis growth in the lungs of mice during acute infection. For all groups, n = 7 except for T3 (n = 5) and RMP 15 (n = 6). T3, untreated and sacrificed at 3 days postinfection; T10, untreated and sacrificed at 10 days postinfection; CMC, treated orally (p.o.) with 0.5% carboxymethyl cellulose; RMP 15, treated p.o. with 15 mg/kg rifampin in 0.5% CMC; blank micelle, treated s.c. with 640 mg/kg blank micelle; ECM 20, treated s.c. with 20 mg/kg ECM; ECM 32, treated s.c. with 32 mg/kg ECM. CMC, RMP 15, blank micelle, ECM 20, and ECM 32 mice were sacrificed 28 days postinfection. Values are means ± SD. Multiple comparisons among pairs were performed by Bonferroni's method (43). There were significant differences between all (P < 0.01) results except between T10 and ECM 32.