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. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: Biochim Biophys Acta. 2015 Jan 20;1850(4):832–844. doi: 10.1016/j.bbagen.2015.01.011

Figure 2. Genetic silencing of GSK3 potentiates Nav1.2-encoded peak current densities.

Figure 2

Representative traces (A) of Nav1.2-derived currents under scrambled RNA conditions (left) or siRNA targeted to GSK3 (right). A current-voltage relationship graph (B) demonstrates the potentiation seen with genetic silencing of GSK3 (red) when compared to scramble control (black). Validation of the RNA construct with Western blot of total cell lysate probed using the indicated antibody is shown in C (reprinted from [29] with permission). A summary bar graph represents the mean current density at 0 mV for both conditions (D). The voltage-dependence of activation and voltage-dependence of steady-state inactivation are shown in E and F, respectively. Results are summarized in Table 1. *(p<0.05).