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. Author manuscript; available in PMC: 2016 Mar 1.
Published in final edited form as: Dev Psychobiol. 2015 Jan 21;57(2):168–176. doi: 10.1002/dev.21272

Figure 5.

Figure 5

Schematic diagram of the neural circuitry underlying acquisition of delay eyeblink conditioning. Conditioned stimulus (CS) input is projected to the cerebellum via the pontine nucleus (PN) mossy fiber projection to the anterior interpositus nucleus (IPN) and Purkinje cells (PC) in the cortex. Unconditioned stimulus (US) input is projected to the cerebellum via the climbing fiber projection from the inferior olive (IO). Conditioned response (CR) is generated through projections from the IPN to the red nucleus (RN), and then the facial motor nucleus (not shown). The medial septum (mSep) projects to the hippocampus (Hippo) and contributes to the generation of theta. The hippocampus sends a feedback projection to the septum. The hippocampus influences the cerebellum through the anterior cingulate cortex (ACC) and/or other cortical areas.