Percent inhibition of cell density with birinapant ± TNF or TRAIL, A, and docetaxel, B, over a range of concentrations was determined during log growth phase on day 3 by XTT assay. Data points from 6 replicates per concentration were used to compare to controls to calculate percentages of inhibition. The mean and SD were plotted and shown, with IC50 determined by non-linear four parametric regression. TNF or TRAIL enhanced curves were significantly different from birinapant alone (p<0.01).