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. Author manuscript; available in PMC: 2015 Aug 19.
Published in final edited form as: Nature. 2014 Dec 3;518(7539):404–408. doi: 10.1038/nature13974

Extended Data Figure 4. CSPG and ISP regulation of Erk1/2.

Extended Data Figure 4

Western blot analysis revealed a significant decrease in the phosphorylation ratio of Erk1/2 in SH-SY5Y cells plated on laminin (2µg/ml) + CSPGs (15µg/ml) compared to laminin only substrates which was reversed by either pre-treatment with ChABC (0.1 U/ml) or 4d ISP treatment (2.5µM). Data normalized to laminin control. N= 4 independent experiments. One way ANOVA, Tukey’s post hoc test, * <0.05 vs all other conditions.