Fig. 6.

Up-regulation of P2X1 and P2Y₂ receptor mRNA levels in hearts from congestive heart failure (CHF) rats. P2X1 and P2Y₂ receptor mRNA molecule numbers/μg total RNA in the myocardium from sham operated and CHF rats. Values are means + s.e.m., n = 7–8. For each, receptor measurements were performed with the same concentration total RNA together with five increasing concentrations of competitor standard. The upper band represents the wild-type product and the lower band represents the competitor product. The left set represents a sham operated rat and the right the CHF rat. There is a clear shift in the equivalence point (arrow) in the CHF rat towards the right (higher concentration) for both the P2X1 and P2Y₂ receptor (reproduced from [488], with permission from Elsevier)