Table 4. Distribution of HLA class I and HLA class I genotype ligands in HCV-negative and in patients with HCV infection and different outcomes.
| HLA and HLA genotype ligands | HCV—neg No. (%) | HCV patients | |||||
|---|---|---|---|---|---|---|---|
| Chronic HCV No. (%) | Hepatocellular carcinoma No. (%) | Lymphoproliferative disorder | |||||
| Cryoglobulinemia syndrome No. (%) | Non-Hodgkin lymphoma No. (%) | Total lymphoproliferative diosrders No. (%) | |||||
| Total patients | 501 (100.0) | 125 (100.0) | 118 (100.0) | 75 (100.0) | 78 (100.0) | 153 (100.0) | |
| HLA—A | |||||||
| A03/A11 | At least one allele | 127 (25.4) | 41 (32.8) | 32 (27.1) | 11 (14.7) | 19 (24.4) | 30 (19.6) |
| Absent | 374 (74.6) | 84 (67.2) | 86 (72.9) | 64 (85.3) | 59 (75.6) | 123 (80.4) | |
| P-value a | Ref. | ns | - | - | 0.01 | ||
| HLA-B | |||||||
| Bw6 | At least one allele | 410 (81.8) | 105 (84.0) | 96 (81.4) | 55 (73.3) | 65 (83.3) | 120 (78.4) |
| Absent | 91 (18.2) | 20 (16.0) | 22 (18.6) | 20 (26.7) | 13 (16.7) | 33 (21.6) | |
| P-value a | Ref. | ns | - | - | ns | ||
| P-value b | ns | ns | Ref. | ns | - | ||
| Bw4 | At least one allele | 326 (65.1) | 87 (69.6) | 82 (69.5) | 57 (76.0) | 44 (56.4) | 101 (66.0) |
| Absent | 175 (34.9) | 38 (30.4) | 36 (30.5) | 18 (24.0) | 34 (43.6) | 52 (34.0) | |
| P-value a | Ref. | ns | - | - | ns | ||
| P-value b | ns | ns | Ref. | 0.02 | - | ||
| Bw6/Bw4 | Bw4-Bw4 | 91 (18.2) | 20 (16.0) | 22 (18.6) | 20 (26.7) | 13 (16.7) | 33 (21.6) |
| Bw6-Bw4 | 235 (46.9) | 67 (53.6) | 60 (50.9) | 37 (49.3) | 31 (39.7) | 68 (44.4) | |
| Bw6-Bw6 | 175 (34.9) | 38 (30.4) | 36 (30.5) | 18 (24.0) | 34 (43.6) | 52 (34.0) | |
| P-value a | Ref. | ns | - | - | ns | ||
| P-value b | ns | ns | Ref. | 0.03 | - | ||
| Bw4–80I | At least one allele | 233 (46.5) | 62 (49.6) | 57 (48.3) | 45 (60.0) | 25 (32.0) | 70 (45.7) |
| Absent | 268 (53.5) | 63 (49.6) | 61 (51.7) | 30 (40.0) | 53 (68.0) | 83 (54.3) | |
| P-value a | Ref. | ns | - | - | ns | ||
| P-value b | ns | ns | Ref. | <0.01 | - | ||
| Bw4–80T | At least one allele | 138 (27.5) | 35 (28.0) | 32 (27.1) | 21 (28.0) | 28 (35.9) | 49 (32.0) |
| Absent | 363 (72.5) | 90 (72.0) | 86 (72.9) | 54 (72.0) | 50 (64.1) | 104 (68.0) | |
| P-value a | Ref. | ns | - | - | ns | ||
| P-value b | ns | ns | Ref. | ns | - | ||
a Fisher’s exact test with chronic HCV infection as reference; b Fisher’s exact test with cryoglobulinemia syndrome as reference.