Table 5. Distribution of KIR/HLA combinations in HCV-negative and in patients with HCV infection and different outcomes.
| KIR gene/ HLA—ligand | HCV—neg No. (%) | HCV patients | |||||
|---|---|---|---|---|---|---|---|
| Chronic HCV No. (%) | Hepatocellular carcinoma No. (%) | Lymphoproliferative disorder | |||||
| Cryoglobulinemia syndrome No. (%) | Non-Hodgkin lymphoma No. (%) | No. (%) | |||||
| Total patients | 501 (100.0) | 125 (100.0) | 118 (100.0) | 75 (100.0) | 78 (100.0) | 153 (100.0) | |
| 3DL1 | Expressed | 468 (93.4) | 113 (90.4) | 116 (98.3) | 70 (93.3) | 74 (94.9) | 144 (94.1) |
| Not expressed | 33 (6.6) | 12 (9.6) | 2 (1.7) | 5 (6.7) | 4 (5.1) | 9 (5.9) | |
| P-value a | Ref. | 0.01 | - | - | ns | ||
| 3DL1/Bw4 | Expressed | 307 (65.6) | 76 (67.3) | 81 (69.8) | 53 (75.7) | 41 (55.4) | 94 (65.3) |
| Not expressed | 161 (34.4) | 37 (32.7) | 35 (30.2) | 17 (24.3) | 33 (44.6) | 50 (34.7) | |
| P-value a | Ref. | ns | - | - | ns | ||
| P-value b | ns | 0.05 | 0.01 | Ref. | - | ||
| 3DL1/Bw4-I80 | Expressed | 217 (46.4) | 54 (47.8) | 56 (48.3) | 41 (58.6) | 23 (31.1) | 64 (44.4) |
| Not expressed | 251 (53.6) | 59 (52.2) | 60 (51.7) | 29 (41.4) | 51 (68.9) | 80 (55.6) | |
| P-value a | Ref. | ns | - | - | ns | ||
| P-value b | 0.03 | 0.02 | <0.01 | Ref. | - | ||
| 2DS4 | Expressed | 469 (93.6) | 114 (91.2) | 116 (98.3) | 70 (93.3) | 74 (94.9) | 144 (94.1) |
| Not expressed | 32 (6.4) | 11 (8.8) | 2 (1.7) | 5 (6.7) | 4 (5.1) | 9 (5.9) | |
| P-value a | Ref. | 0.02 | - | - | ns | ||
| 2DS4/Cw04 | Expressed | 132 (28.1) | 33 (29.0) | 35 (30.2) | 21 (30.0) | 31 (41.9) | 52 (36.1) |
| Not expressed | 337 (71.9) | 81 (71.0) | 81 (69.8) | 49 (70.0) | 43 (58.1) | 92 (63.9) | |
| P-value a | Ref. | ns | - | - | ns | ||
| 3DL2/A03 or A11 | Expressed | 127 (25.3) | 41 (32.8) | 32 (27.1) | 11 (14.7) | 19 (24.4) | 30 (19.6) |
| Not expressed | 374 (74.6) | 84 (67.2) | 86 (72.9) | 64 (85.3) | 59 (75.6) | 123 (80.4) | |
| P-value a | Ref. | ns | - | - | 0.01 | ||
| P-value a | Ref. | ns | <0.01 | ns | - | ||
a Fisher’s exact test with chronic HCV infection as reference; b Fisher’s exact test with Non-Hodgkin lymphoma as reference;