FIG 2.

Conservation of M. marinum and M. tuberculosis chromosomal loci involved in PGL-PDIM production. The five M. marinum genes targeted for mutational analysis (Δ, deletion; *, amino acid substitution) in this study and their respective orthologs in M. tuberculosis are highlighted with pattern-filled arrows. †, pks15/1 is essential for PGL production. The gene pks15/1 is disrupted (split into pks1 and pks15) by natural mutations in M. tuberculosis H37Rv and other Euro-American lineage strains, thus leading to PGL deficiency (18, 64). Additional genes implicated in PGL and/or PDIM production located downstream of fadD29 are not depicted. Adapted from reference 13 with permission of the publisher.