Table 3.

Allele and genotype frequencies within the IL10 gene locus in patients with atherosclerotic and aortic aneurysmal vascular disease (VD) with (w/) or without (wo/) chronic periodontitis (CP)

		Allele frequency
		VD w/CP	VD wo/CP	p (VD w/CP vs. VD wo/CP) (chi-square)
IL10a	SNP −1082 rs1800896	n=70	n=74
1	A	0.53 (37)c	0.64 (47)	0.2
2	G	0.47 (33)	0.36 (27)
IL10a	SNP −819 rs1800871	n=70	n=74
1	C	0.79 (55)	0.64 (47)	0.047 d
2	T	0.21 (15)	0.36 (27)
IL10a	SNP −592 rs1800872	n=70	n=74
1	C	0.79 (55)	0.62 (46)	0.03 e
2	A	0.21 (15)	0.38 (28)
		VD w/CP	VD wo/CP	Genotype frequency p (VD w/CP vs. VD wo/CP) (chi-square)	p (VD w/CP vs. VD wo/CP) (logistic regression model)
IL10b	SNP −1082 rs1800896	n=35	n=37
1/1	A/A	0.26 (9)c	0.35 (13)	0.39	0.23
1/2	A/G	0.54 (19)	0.57 (21)	0.83	0.94
2/2	G/G	0.20 (7)	0.08 (3)	0.18	0.14
IL10b	SNP −819 rs1800871	n=35	n=37
1/1	C/C	0.63 (22)	0.35 (13)	0.02 f	0.02 g
1/2	C/T	0.31 (11)	0.56 (21)	0.03 h	0.03 i
2/2	T/T	0.06 (2)	0.08 (3)	1	0.8
IL10b	SNP −592 rs1800872	n=35	n=37
1/1	C/C	0.63 (22)	0.32 (12)	0.01 j	0.02 k
1/2	C/A	0.31 (11)	0.59 (22)	0.02 l	0.02 m
2/2	A/A	0.06 (2)	0.08 (3)	1	0.8

SNP, single nucleotide polymorphism.

^aAllele designation (1= more frequent, major allele; 2=less frequent, minor allele).

^bGenotype designations.

^cNumber of alleles and genotypes in parentheses.

^dOR=0.52, 95% CI=1.003–4.42.

^eOR=2.23, 95% CI=1.07–4.68.

^fOR=3.12, 95% CI=1.19–8.2.

^gOR=3.69, 95% CI=1.2–11.4.

^hOR=0.35, 95% CI=0.13–0.92.

ⁱOR=0.28, 95% CI=0.09–0.88.

^jOR=3.53, 95% CI=1.33–9.31.

^kOR=4.0, 95% CI=1.28–12.35.

^lOR=0.31, 95% CI=0.12–0.82.

^mOR=0.26, 95% CI=0.08–0.82.

In the binary logistic regression model the genotypic differences were adjusted for the effect of age, gender, body mass index, diabetes, and smoking status.