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. 2015 Feb 17;108(4):799–809. doi: 10.1016/j.bpj.2014.12.022

Figure 2.

Figure 2

Model with newly measured cortical flows faithfully captures the experimental data. (A) Average GFP::PAR-2 protein distribution during polarity establishment at 24°C (n = 47), overlaid with segmentation of domain center (dashed line) and domain expansion (dark gray). Time zero in this figure: onset of polarity establishment, as identified by domain segmentation. (B) Polarity establishment as predicted by M1 (Table S1 (13)), overlaid with the segmentation of this prediction (light gray) and of our experimental data (dark gray). Arrowheads indicate leading front enrichment not observed in (A). (C) Cortical flows measured using VIT-2::GFP particle tracking (Fig. S4 and the Supporting Material). (D) Polarity establishment as predicted by M2 (i.e., M1 with flows shown in C), overlaid with landmarks similar to (B). Note the strong dampening of leading edge enrichment. To see this figure in color, go online.