Table 2.
Proteomic identification of brittle star skeletal proteins in tube foot
| Ophiocoma wendtii ID | Domains identified, possible homology | NCBI entry [Sea Urchin] top hits | Presence in sea urchin skeletal proteome | Ophiocoma wendtii | Designation |
|---|---|---|---|---|---|
| gastrula ID | |||||
| Extracellular matrix components | |||||
| 50743 | C-Type Lectin | XP_003730279.1 | C-Type lectins found in all | LUPK | SM22 |
| 7123 | C-Type Lectin | XP_003730279.1 | C-Type lectins found in all | 266 | SM24 |
| 40110 | C-Type Lectin | XP_790287.2 | C-Type lectins found in all | 1464 | SM21 |
| 4220 | C-Type Lectin | NP999836.1 | C-Type lectins found in all | none | SM20 |
| 40467 | ECM-3 like | XP_003724641.1 | Found in all | none | |
| 67843/74501 | Fibrinogen C | XP_783504.2 | Spicule and tooth | TF only, similar to PO24 | |
| Protease domains | |||||
| 5998 | Matrix Metalloproteinase | XP_791616.2 | MMP's found in all | TF only, similar to NAKRO | |
| Other proteins identified | |||||
| 2696 | LDL receptor-like | XP_780169.2 | Found in all | TF only, similar to M7PKJ | |
| 6749 | SCP domain | XP_781255 | Similar domains present | TF only, similar to 2581 | |
| 32153 | Gelsolin-like | XP_788777.2 | Spine and tooth | none | |
| 68329 | Semaphorin 6D | XP_003729425.1 | Spicule, test and tooth | none | |
| 7643 | Anion Exchange Pump | XP_791964.2 | Spine and Tooth | none | |
| 3983 | Actin | NP_999634.1 | Found in all | Homology unclear | |
| 9834 | Actin | 1101351C | Found in all | Homology unclear | |
| 5596 | Beta-Tubulin | XP_791790.1 | Test and Spine | TF only, similar to 842 | |
| 2896 | Collagen | XP_795694.2 | Found in all | Homology unclear | |
| 9902 | Collagen | NP_999675.1 | Found in all | Homology unclear | |
| 3947 | Collagen | NP_999675.1 | Found in all | Homology unclear | |
| 453 | Myosin | XP_785810.2 | Tooth | Homology unclear | |
| 7471 | Ubiquitin | P23398.2 | Found in all | Homology unclear | |
| 3703 | Ig Domain | XP_003723404.1 | ? | ? | |
| 4964 | Cation channel? | XP_003727536.1 | ? | ? | |
| 9877 | Cation channel? | XP_784612.2 | ? | ? | |
| 3 | Unknown | XP_003729030 | ? | ? | |
| 2030 | Unknown | XP_794671.2 | ? | ? | |