Table 2.
Appearance of minor drug resistance mutations in PR gene*
| Mutation | Frequency (%) | |||
|---|---|---|---|---|
| All (n = 52) | CRF01_AE (n = 47) | Subtype B (n = 4) | G/CRF01_AE (n = 1) | |
| L10I/V | 11 (21.2) | 10 (21.3) | 1 (25.0) | 0 (0) |
| G16E | 16 (30.8) | 15 (31.9) | 1 (25.0) | 0 (0) |
| K20R | 19 (36.5) | 19 (40.4) | 0 (0) | 0 (0) |
| L33F | 7 (13.5) | 7 (14.9) | 0 (0) | 0 (0) |
| M36I/L | 46 (88.5) | 45 (95.7) | 0 (0) | 1 (100) |
| I62V | 6 (11.5) | 6 (12.8) | 0 (0) | 0 (0) |
| L63P | 5 (9.6) | 4 (8.5) | 0 (0) | 1 (100) |
| I64V | 3 (5.8) | 2 (4.3) | 1 (25.0) | 0 (0) |
| H69K/R | 48 (92.3) | 47 (100) | 0 (0) | 1 (100) |
| V77I | 12 (23.1) | 10 (21.3) | 2 (50.0) | 0 (0) |
| V82I | 3 (5.8) | 3 (6.4) | 0 (0) | 0 (0) |
| L89M/I | 48 (92.3) | 47 (100) | 0 (0) | 1 (100) |
| I93L | 15 (28.8) | 12 (25.5) | 3 (75.0) | 0 (0) |
*Mutations were detected manually according to the International AIDS Society-USA panel.