Table 2.
General features and serum biochemical analyses in rats fed with choline-deficient L-amino acid defined (CDAA) diet receiving fluvastatin (Flu) or vehicle treatment compared with normal controls
| Groups | 4 wk | 8 wk | ||||||
|---|---|---|---|---|---|---|---|---|
| Control | CDAA | CDAA + Flu (5 mg/kg) | CDAA + Flu (10 mg/kg) | Control | CDAA | CDAA + Flu (5 mg/kg) | CDAA + Flu (10 mg/kg) | |
| Numbers | 4 | 8 | 8 | 8 | 4 | 8 | 8 | 8 |
| Steatosis score | 0.00 ± 0.00 | 3.00 ± 0.00 ** | 3.00 ± 0.00 ** | 2.70 ± 0.95 ** | 0.00 ± 0.00 | 3.00 ± 0.00 ** | 3.00 ± 0.00 ** | 2.25 ± 1.17 # |
| Hepatocyte ballooning | 0.0 ± 0.0 | 2.0 ± 0.0 ** | 2.0 ± 0.0 ** | 2.0 ± 0.0 ** | 0.0 ± 0.0 | 2.0 ± 0.0 ** | 2.0 ± 0.0 ** | 1.5 ± 0.8 ** |
| Inflammation | 0.00 ± 0.00 | 0.60 ± 0.52 | 0.80 ± 0.42 ** | 0.40 ± 0.52 | 0.00 ± 0.00 | 1.17 ± 0.25 ** | 1.60 ± 0.39 ** | 1.0 ± 0.55 **,† |
| Fibrosis score | 0.00 ± 0.00 | 1.80 ± 0.42 ** | 1.20 ± 0.42 # # | 0.70 ± 0.48# #, † | 0.00 ± 0.00 | 1.67 ± 0.56 ** | 1.15 ± 0.63 ** | 0.58 ± 0.92 # |
| BW (g) | 312 ± 7 | 245 ± 9 ** | 217 ± 6 ** | 195 ± 8 **## | 467 ± 10 | 442 ± 12 | 419 ± 7 ** | 399 ± 7 **# |
| LW (g) | 10.9 ± 0.4 | 18.1 ± 0.9 ** | 14.7 ± 0.9 ** # | 14.3 ± 0.4 **## | 14.3 ± 0.6 | 23.5 ± 0.9 ** | 20.3 ± 0.7 ** | 18.2 ± 1.8 ## |
| AST (U/L) | 96 ± 13 | 503 ± 89 * | 439 ± 90 * | 366 ± 72 | 77 ± 4 | 373 ± 30 ** | 311 ± 26 ** | 267 ± 49 ** |
| ALT (U/L) | 25 ± 2 | 134 ± 28 * | 160 ± 25 ** | 121 ± 20 | 25 ± 5 | 161 ± 16 ** | 125 ± 11 ** | 84 ± 24 ## |
| Cr (mg/dL) | 0.43 ± 0.02 | 0.51 ± 0.05 | 0.48 ± 0.03 | 0.47 ± 0.04 | 0.40 ± 0.00 | 0.42 ± 0.01 | 0.44 ± 0.02 | 0.41 ± 0.01 |
| TG (mg/dL) | 47.5 ± 5.3 | 22.9 ± 1.9 ** | 26.4 ± 2.79 ** | 29.7 ± 4.7 * | 58 ± 9 | 30 ± 4 * | 24 ± 3 * | 41 ± 7 |
| Cholesterol (mg/dL) | 69.0 ± 4.4 | 56.4 ± 1.9 | 56.3 ± 2.3 | 60.7 ± 4.4 | 63 ± 6 | 55 ± 2 | 57 ± 2 | 58 ± 4 |
| Glucose (mg/dL) | 158 ± 9 | 124 ± 6 | 132 ± 11 | 126 ± 10 | 134 ± 12 | 123 ± 5 | 127 ± 6 | 132 ± 3 |
| TNFα (pg/mL) | 50 ± 4 | 109 ± 12 ** | 67 ± 11 ## | 64 ± 9 ## | 35 ± 7 | 55 ± 22 * | 30 ± 11 ## | 11 ± 3 # |
*p < 0.05, **p < 0.01 vs. control group, #p < 0.05, ##p < 0.01 vs. CDAA group, †p < 0.05 vs. CDAA + Flu (5 mg/kg). BW: Body weight, LW: Liver weight, AST: Aspartate aminotransferase, ALT: Alanine aminotransferase, Cr: Creatinine, TG: Triglyceride, TNFα: Tumor necrosis factor α.