Table 1.
Experimental groups
| Groups | Description | Novel object intervention | Drug administration | Purpose |
|---|---|---|---|---|
| 1 (n = 12) | Paired housed (Two rats/cage) | YES | None | Control group without isolation and monotony (PHNO) |
| 2 (n = 12) | Paired housed (Two rats/cage) | NO | None | Without isolation and with Monotony (PH) |
| 3 (n = 12) | Paired housed (Two rats/cage) | YES | PCPA: 300 mg/kg (i.p.) (Koe and Weissman, [14]) | Without isolation and monotony + PCPA (PHNOPCPA) |
| 4 (n = 12) | Paired housed (Two rats/cage) | NO | PCPA: 300 mg/kg (i.p.) | Without isolation and with Monotony + PCPA (PHPCPA) |
| 5 (n = 08) | Singly housed isolated rat (one rat/cage) | NO | None | With Isolation and monotony (SH) |
| 6 (n = 08) | Singly housed isolated rat (one rat/cage) | YES | None | With Isolation and without monotony (SHNO) |
| 7 (n = 08) | Singly housed isolated rat (one rat/cage) | YES | PCPA: 300 mg/kg (i.p.) | With Isolation and without monotony + PCPA (SHNOPCPA) |
PCPA: Para chlorophenylalanine (Tryptophan hydroxylase inhibitor).