FIGURE 1.

(A) Sliding window analysis for SLC41A2 haplotype-T2D associations among 3285 Hispanic American WHI women. Window size is 2 SNPs. Sliding window haplotype-based analyses (12) (window width = 2) were used to examine the joint contribution of 2 SNP windows on T2D risk. For each window, a Wald test on the basis of t distribution was used. The test performed N-1 haplotype-specific tests for N haplotypes (of each vs. all others), depending on the number of SNPs in each gene. The dashed line represents a −log₁₀P of 3.08 (corresponding to P = 0.001), which was used as the global significance threshold by Bonferroni’s correction for 61 window frames. (B) Sliding window analysis for MRS2 haplotype-T2D associations among 3285 Hispanic American WHI women. Window size is 2 SNPs. Sliding window haplotype-based analyses (12) (window width = 2) were used to examine the joint contribution of 2 SNP windows on T2D risk. For each window, a Wald test on the basis of t distribution was used. The test performed N-1 haplotype-specific tests for N haplotypes (of each vs. all others), depending on the number of SNPs in each gene. The dashed line represents a −log₁₀P of 2.64 (corresponding to P = 0.002), which was used as the global significance threshold by Bonferroni’s correction for 22 window frames. MRS2, mitochondrial RNA splicing 2 gene; SLC41A2, solute carrier family 41 (anion exchanger), member 2 gene; SNP, single nucleotide polymorphism; T2D, type 2 diabetes; WHI, Women’s Health Initiative.