TABLE 2.
Top 10 associations (ranked by nominal P values among AA women) between ion channel-related genes and diabetes risk in the WHI-SHARe cohort1
| Minor allele frequency (AA/HA) |
AA women (n = 7287) |
HA women (n = 3285) |
||||||
| Locus | SNP | Major/minor allele | Cases | Controls | OR (95% CI) | P (FDR-adjusted P) | OR (95% CI) | P |
| CNNM1 | rs6584273 | G/A | 0.20/0.04 | 0.22/0.05 | 0.84 (0.76, 0.92) | 0.0005 (0.02)* | 1.05 (0.76, 1.44) | 0.76 |
| TRPM6 | rs577787 | T/C | 0.30/0.09 | 0.27/0.08 | 1.15 (1.10, 1.25) | 0.002 (0.09) | 1.14 (0.91, 1.44) | 0.26 |
| ABCC8 | rs7947462 | G/A | 0.07/0.23 | 0.09/0.24 | 0.79 (0.68, 0.92) | 0.002 (0.14) | 0.92 (0.79, 1.08) | 0.29 |
| TRPM6 | rs546862 | T/C | 0.30/0.09 | 0.27/0.08 | 1.14 (1.00, 1.25) | 0.003 (0.09) | 1.17 (0.93, 1.47) | 0.19 |
| CLDN16 | rs4438632 | G/A | 0.04/0.25 | 0.03/0.22 | 1.38 (1.10, 1.70) | 0.003 (0.11) | 1.06 (0.90, 1.24) | 0.48 |
| TRPM6 | rs7046143 | T/C | 0.30/0.24 | 0.27/0.22 | 1.13 (1.00, 1.24) | 0.004 (0.10) | 1.05 (0.90, 1.23) | 0.53 |
| TRPM7 | rs2011064 | C/G | 0.19/0.46 | 0.17/0.45 | 1.16 (1.00, 1.28) | 0.005 (0.09) | 1.02 (0.89, 1.16) | 0.80 |
| CLDN16 | rs1593313 | T/C | 0.06/0.32 | 0.05/0.29 | 1.28 (1.10, 1.53) | 0.006 (0.12) | 1.01 (0.87, 1.18) | 0.87 |
| TRPM7 | rs3109894 | C/T | 0.30/0.47 | 0.28/0.46 | 1.13 (1.00, 1.23) | 0.007 (0.09) | 1.00 (0.88, 1.15) | 0.95 |
| TRPM7 | rs1395297 | T/C | 0.30/0.47 | 0.28/0.46 | 1.12 (1.00, 1.22) | 0.008 (0.09) | 0.99 (0.87, 1.14) | 0.95 |
1
n = 10,572. ORs and 95% CIs were computed by using additive model with multivariate logistic regression models and were adjusted for age, region, and 3 principal components of global ancestry. *FDR-adjusted P ≤ 0.05. AA, African American; FDA, false discovery rate; HA, Hispanic American; SHARe, SNP Health Association Resource; SNP, single nucleotide polymorphism; WHI, Women’s Health Initiative.